Questions about BRCA testing
A significant family history of cancer can be complex. Your included counselling session helps you interpret your result, and you can also involve your GP.
About the test
What is a BRCA test?
It looks for changes in the BRCA1 and BRCA2 genes that are linked to a higher inherited risk of breast and ovarian cancer.
Which genes does the panel cover?
36 genes: APC, ATM, BAP1, BARD1, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, GREM1, HOXB13, MBD4, MITF, MLH1, MSH2, MSH6, MUTYH, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTEN, RAD51C, RAD51D, RNF43, SMAD4, STK11, TP53 and VHL. Together they're linked to inherited breast, ovarian, bowel (including Lynch syndrome), prostate, pancreatic and skin cancer risk.
What kinds of gene change does it detect?
The test uses next-generation sequencing to detect single-letter changes, small insertions and deletions, and copy number changes (larger deleted or duplicated sections). No genetic test finds every possible change, so a negative result can't rule out all inherited risk.
Does a variant mean I'll get cancer?
No. It indicates increased risk, not certainty, and it can help guide screening and prevention with your clinician.
If my result is negative, am I in the clear?
A negative result is reassuring, but it doesn't remove all risk. Your family history still matters, and you should continue with any screening you've been advised to have.
Can men take the test?
Yes. Men can carry BRCA variants and pass them on to their children, and carriers have a higher risk of some cancers, including male breast and prostate cancer.
Does this test check whether I have cancer?
No. It looks at inherited risk only. If you have symptoms such as a breast lump or change, persistent bloating or pelvic pain, see your GP promptly.
Ordering and your sample
Do I need a GP referral?
No. You can order directly.
Could I get this test on the NHS?
If you meet NHS eligibility criteria, for example a strong family history or a relative with a known variant, you may be offered testing free through an NHS clinical genetics service. Speak to your GP if you're unsure. Private testing suits people who don't meet those criteria or would prefer to test directly.
Who can take the test?
Adults aged 18 and over, testing their own sample. Genetic testing of children for adult-onset cancer risk isn't recommended.
How do I give my sample?
Your kit includes instructions for giving a saliva sample at home. You then post it back in the prepaid envelope.
How long do results take?
Results are usually ready within 20 working days of the laboratory receiving your sample.
Is the packaging discreet?
Yes. The kit is sent and returned in discreet packaging, and UK shipping is free.
Results and support
Is genetic counselling included?
Yes. Gene Care's GCRB and AHCS registered genetic counsellors support you before you test and again once your result is ready.
Who analyses and reviews my result?
Your sample is analysed at an ISO 15189:2022 accredited laboratory in Birmingham, and HCPC-registered clinical scientists interpret the findings. A clinician at Northwest Health, a CQC-registered private GP clinic, then reviews your result.
Will my GP be told?
Your result belongs to you. Your counsellor can explain how to share it with your GP if you'd like screening or a referral arranged.
Do I have to tell insurers?
Under the UK Code on Genetic Testing and Insurance, insurers can't ask you to disclose a predictive genetic test result or use it in their decisions, with one narrow exception for Huntington's disease and very large life policies. Check the current Code for full details.
Still have questions?
Email info@bioxmedical.co.uk, or order now and talk everything through with your genetic counsellor.
- 36 genes, including BRCA1, BRCA2 and PALB2
- ISO 15189 accredited UK laboratory
- Genetic counselling before and after your test
- Results reviewed by Northwest Health clinicians
- Free UK shipping and discreet packaging